The U.S. Pharmacopeia's definition of room temperature (20-25 C [68-77 F]) was used for this review. Human milk naturally contains some calcitonin and its precursor, procalcitonin. Monitor serum calcium and symptoms of hypocalcemia in patients with a history of hypocalcemia or a mineral metabolism disorder. For the treatment of hypercalcemia, calcium supplements should be avoided. The time to 90% potency (T90) ranged from 32.0 hours to 41.7 hours. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. $O./ 'z8WG x 0YA@$/7z HeOOT _lN:K"N3"$F/JPrb[}Qd[Sl1x{#bG\NoX3I[ql2 $8xtr p/8pCfq.Knjm{r28?. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. There are no adequate studies of calcitonin-salmon injection during pregnancy to inform a drug associated risk for birth defects or miscarriage. The recommended dosage is 100 IU daily or 50 IU twice daily administered subcutaneously or intramuscularly. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. Has been used in the treatment of glucocorticoid-induced osteoporosis [off-label]; however, other therapies (e.g., oral bisphosphonates) are preferred. [0 /XYZ 69.5999999 112.799999 0] Hypocalcemia associated with tetany and seizure activity has been reported with calcitonin therapy. Fracture reduction efficacy has not been demonstrated. ADVERSE REACTIONS: The most common adverse reactions are nausea with or without vomiting (10%), injection site inflammation (10%), and flushing of the face or hands (2% to 5%). Administer by sub-Q or IM injection (Paget disease of bone, hypercalcemia, postmenopausal osteoporosis) or intranasally (postmenopausal osteoporosis). AHFS DI Essentials. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. M I A C A L C I N \( c a l c i t o n i n s a l m o n \) i n j e c t i o n , s y n t h e t i c , f o r s u b c u t a n e o u s o r i n t r a m u s c u l a r u s e I n i t i a l U . Type I, clear glass ampoule containing 1 ml of solution. 2007;64(16):1711-1715. The effect is more evident on initiation of therapy and tends to decrease or disappear with continued administration or a reduction in dose. Each bottle contains at least 30 doses. 467.039999 0] For the treatment of hypercalcemia, vitamin D preparations should be avoided. You must declare any conflicts of interest related to your comments and responses. Possibility of hypocalcemic tetany following parenteral administration; have calcium injection readily available, particularly during first several doses of parenteral calcitonin. 4c'I\o%:CfPtly8DVagJ 0\O1T5,T57*AZk.nzmJQS^uXh3B@TJ?C03I)^x \1:8b3b-ap\^Ooy55SV4>mZ1>8-i%;AHJ1ANK~._$lMa|j{'Zfkhc b}/L-Dmr!neJIbe?F',Z1$~o@2Qm_D5=xc[% 5w[7vqzX?sXlzvu.u+ZDBZ-Q g8SmT}n Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. /Type /Page Use the following dosage schedule guidelines: If your usual dose is two doses per day, use the missed dose if you remember it within 2 hours of your regularly scheduled dose. x][o~_93EK! Store calcitonin salmon injection in its original container in the refrigerator. Calcitonin is a human hormone that is also found in salmon. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Miacalcin Nasal Spray Storage (or generic equivalent): After opening, store bottle in use at room temperature between 20 and 25 degrees C (68 and 77 degrees F) in an upright position, for up to 35 days. Safety and efficacy have not been established; off-label use reported for selected conditions. For the treatment of hypercalcemia, vitamin D preparations should be avoided. By using this Site you agree to the following, By using this Site you agree to the following, Miacalcin injection prescribing information. %%EOF Calcitonin salmon prepared by recombinant DNA technology is structurally identical to calcitonin salmon produced by chemical synthesis. This medicinal product contains 3.3 mg sodium per ml, equivalent to 0.16% of the WHO recommended maximum daily intake of 2 g sodium for an adult. /Annots 20 0 R hb```M~ cc`aq@a/O(C" H82t*\S, j2UFMzCD(ztZh PZa0J i`1@ Importance of women informing clinicians if they are or plan to become pregnant or to breast-feed. Calcitonin salmon injection is also used sometimes to treat osteogenesis imperfecta. /Pattern << The dose of lithium may require adjustment. Hypocalcemia must be corrected before initiating therapy. Following parenteral administration of 100 IU calcitonin, peak plasma concentration lies between about 200 and 400 pg/ml. [0 /XYZ 69.5999999 An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. 285.599999 0] endobj Solution for injection/infusion (injection/infusion). Therefore, the metabolic clearance is much lower in patients with end-stage renal failure than in healthy subjects. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. Miacalcin injection should be The admixtures with added buffer were studied under refrigerated storage as well. Uses for Miacalcin. Reserve use for patients that are more than 5 years postmenopause in whom alternative treatments are not suitable (e.g., patients for whom other therapies are contraindicated or for patients who are intolerant or unwilling to use other therapies). Calcitonin (salmon, synthetic) . Within each frequency grouping, adverse drug reactions are presented in order of decreasing seriousness. /MediaBox [0 0 612 792] Calcitonin-salmon injection is administered intramuscularly or subcutaneously. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Of the 189 medications listed in AHFS Drug Information 2006 for storage in a . In animals, salmon calcitonin has been shown to decrease lactation and to be excreted in milk (see section 5.3). endobj 12 0 obj For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Calcitonin 50 IU/1 ml solution for injection and infusion . xS*B.C 4T0 \.LcC4.TO+cCC#,.@ 30 In severe or emergency cases, intravenous infusion with up to 10 IU/kg body weight in 500 ml 0.9% w/v sodium chloride solution may be administered over a period of at least 6 hours. Most events were mild in intensity. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Vitamin D analogs: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. [0 /XYZ 43.6799999 Calcitonin does not appear to cross the placenta. Of the 189 medications listed in AHFS Drug Information 2006 for storage in a refrigerator,[9] 89 were present in our pharmacy department's refrigerator and were included in this review. Neoplasms benign, malignant and unspecified (incl cysts and polyps). For the treatment of hypercalcemia, calcium supplements should be avoided. MIACALCIN is a registered trademark of Novartis AG, licensed to the Viatris Companies. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you are using calcitonin salmon for osteoporosis, it is important that you get enough calcium and vitamin D. Your doctor may prescribe supplements if your dietary intake is not enough. W.+kM8]9l) K!=WJkb Guidelines recommend against calcitonin-salmon for the treatment of osteoporosis; the efficacy of calcitonin in preventing vertebral and non-vertebral fractures is not established, and the increase in bone mineral density observed is less than that reported for other agents (e.g., bisphosphonates). [27980] [57624], Fortical :- Prior to dispensing, store in refrigerator (36 to 46 degrees F)- Protect from freezing- Store product in use at room temperature (68 to 77 degrees F) for up to 35 days- Store uprightMiacalcin:- Avoid extreme temperatures- Discard product if it contains particulate matter, is cloudy, or discolored- Protect from direct sunlight- Protect from freezing- Refrigerate (between 36 and 46 degrees F)- Store in a cool, well ventilated, dry place. endobj redness, swelling, or irritation at the site of injection, flushing (feeling of warmth) of the face or hands. Experience with the use of calcitonin in the elderly has shown no evidence of reduced tolerability or altered dosage requirements. [57624]Miacalcin Nasal Spray Storage (or generic equivalent): After opening, store bottle in use at room temperature between 20 and 25 degrees C (68 and 77 degrees F) in an upright position, for up to 35 days. Serious allergic-type reactions such as bronchospasm, swelling of the tongue and throat, anaphylactic shock. From a microbiological point of view, this medicine should be used immediately after it has reached room temperature if it is to be injected or immediately after dilution in 0.9% w/v sodium chloride in soft PVC bags only, if it is to be infused. /PCSp 4 0 R Calcitonin may cause fatigue, dizziness and visual disturbances (see section 4.8) which may impair the patient's reaction. Therefore, breast-feeding is not recommended during treatment. With IM or sub-Q administration, 824 hours. Keep all supplies in a clean, dry place and out of reach of children. Duration of treatment should not normally exceed 3 months due to evidence of an increased risk of malignancies with long term calcitonin use. 19 0 obj A detailed skin testing protocol is available from the manufacturers; consult the specific prescribing information for contact information for the skin testing protocol. Prepared synthetically or using recombinant DNA technology; contains the 32 amino acids in the same linear sequence as occurs in natural calcitonin of salmon origin. Inhibits lactation in animals. Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. Calcitonin ampoules 50 IU/ml should be inspected visually. Results: Of the 189 medications listed in AHFS Drug Information 2006 for storage in a. Calcitonin is excreted primarily in the urine as inactive metabolites. When suggestions are available use up and down arrows to review and ENTER to select. Max: 8 International Units/kg IM or subcutaneously every 6 hours. [63474] Calcitonin should be used only in patients who do not respond to alternative treatments or for whom such treatments are not suitable (e.g., patients for whom other therapies are contraindicated or for patients who are intolerant or unwilling to use other therapies).[52559]. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Calcium; Vitamin D: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. Keep all appointments with your doctor and laboratory. Do not freeze this medicine or shake the vials. General disorders and administration site conditions. Calcitonin-salmon appears to have actions essentially identical to endogenous calcitonin of mammalian origin, but its potency per mg is greater than endogenous calcitonin, and it has a longer duration of action. In addition, salmon calcitonin could be administered by intravenous injection after previous rehydration. Miacalcin: To prime pump, hold bottle upright and depress the 2 white side arms of pump toward the bottle until full spray is produced. For the treatment of hypercalcemia, vitamin D preparations should be avoided. Experience with calcitonin in children with idiopathic juvenile osteoporosis is very limited; the relationship between this disorder and postmenopausal osteoporosis is not established. endobj Mylan Institutional LLC. Musculoskeletal and connective tissue disorders. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Carefully consider the benefits for the individual patient against the possible risks. Store bottle in use at room temperature between 15C-30C (59F-86F) in an upright Do not use more or less of it or use it more often than prescribed by your doctor. Calcitonin receptor down-regulation may also result in a reduced clinical response in a small percentage of patients following long-term therapy. Calcitonin has a short absorption half-life of 10-15 minutes. In addition, it appears to be quite beneficial in preventing bone loss after liver transplantation. /Type /ExtGState Monitor by periodic determinations of serum alkaline phosphatase and urinary hydroxyproline excretion as well as evaluation of symptoms. Calcitonin is given parenterally (preferably by subcutaneous or intramuscular injection) or intranasally since calcitonin is destroyed in the GI tract. The dose may be reduced to 50 IU daily at the start of remobilisation. Peak plasma concentrations are attained within the first hour of administration. To prime the pump before it is used for the first time, the bottle should be held upright and the two white If your usual dose is three times a week, give the missed dose on the next day and continue every other day thereafter. Antibody Formation: Circulating antibodies to calcitonin salmon have been reported with Miacalcin injection. Otherwise, skip the missed dose and then continue on the regular dosing schedule. [27980] When sprayed into the nose, miacalcin is quickly absorbed into the blood stream. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. For the treatment of hypercalcemia, calcium supplements should be avoided. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. << [24299] Guidelines recommend against calcitonin-salmon for the treatment of osteoporosis; the efficacy of calcitonin in preventing non-vertebral fractures is not established, and the increase in bone mineral density observed is less than that reported for other agents (e.g., bisphosphonates). It is not known whether salmon calcitonin crosses the placental barrier. Serum calcium levels may be transiently decreased to below normal levels following administration of calcitonin, notably upon initiation of therapy in patients with abnormally high rates of bone turnover. endobj Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. American Journal of Health-System Pharmacy, Regranex topical gel (Ortho-McNeil-Janssen), Diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus vaccine combined, Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, Erythromycin ethylsuccinate oral suspension, Enbrel (Immunex Corporation [Amgen and Wyeth Pharmaceuticals]), Repeated periods of exposure for a combined maximal duration of 6 days, Filgrastim vials and Singleject prefilled syringes, Insulin glargine (rDNA origin) vial or cartridge, Lantus vial or cartridge (Sanofi-Aventis), 70% insulin aspart protamine suspension and 30% insulin as part injection (rDNA origin) pen fill cartridge, Novolog Mix 70/30 pen fill cartridge (Novo Nordisk), 70% insulin aspart protamine suspension and 30% insulin as part injection (rDNA origin) vial, Lente human insulin (rDNA origin) zinc suspension, NPH, human insulin isophane suspension (rDNA origin), Regular human insulin injection (rDNA origin), Humulin Ultralente human insulin (rDNA origin) extended zinc suspension, Neomycin sulfate-polymixin B sulfate solution for irrigation, Neosporin G.U. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Reactions have included anaphylaxis with death, bronchospasm, and swelling of the tongue or throat. IM injection preferred when injection volume >2 mL. With intranasal therapy, rhinitis, nasal symptoms, back pain. Commenting is limited to medical professionals. Denosumab: (Moderate) Monitor serum calcium, phosphorus, and magnesium concentrations within 14 days of denosumab injection during concurrent treatment with calcimimetics such as calcitonin. The U.S. Pharmacopeia's definition of room-temperature (20-25 C [68-77 F]) was used. Paricalcitol: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. new primary malignancy / Delayed / 4.1-4.1bronchospasm / Rapid / 1.0-3.0stroke / Early / 0-1.0myocardial infarction / Delayed / 0-1.0hearing loss / Delayed / 0-1.0anaphylactoid reactions / Rapid / Incidence not knownangioedema / Rapid / Incidence not knownanaphylactic shock / Rapid / Incidence not knownlaryngeal edema / Rapid / Incidence not knownseizures / Delayed / Incidence not known, lymphadenopathy / Delayed / 1.0-3.0constipation / Delayed / 1.0-3.0depression / Delayed / 1.0-3.0hypertension / Early / 1.0-3.0angina / Early / 1.0-3.0cystitis / Delayed / 0-3.0conjunctivitis / Delayed / 1.0-3.0skin ulcer / Delayed / 0-1.0anemia / Delayed / 0-1.0dyspnea / Early / 0-1.0gastritis / Delayed / 0-1.0migraine / Early / 0-1.0palpitations / Early / 0-1.0sinus tachycardia / Rapid / 0-1.0bundle-branch block / Early / 0-1.0phlebitis / Rapid / 0-1.0cholelithiasis / Delayed / 0-1.0hepatitis / Delayed / 0-1.0hyperthyroidism / Delayed / 0-1.0goiter / Delayed / 0-1.0nephrolithiasis / Delayed / 0-1.0hematuria / Delayed / 0-1.0peripheral edema / Delayed / 0-1.0edema / Delayed / 0-1.0blurred vision / Early / 0-1.0antibody formation / Delayed / 10.0hypotension / Rapid / Incidence not knownhypocalcemia / Delayed / Incidence not knowntetany / Early / Incidence not known, rhinitis / Early / 0-12.0injection site reaction / Rapid / 10.0-10.0vomiting / Early / 1.8-10.0nausea / Early / 1.8-10.0flushing / Rapid / 0-5.0back pain / Delayed / 5.0-5.0arthralgia / Delayed / 3.8-3.8epistaxis / Delayed / 3.5-3.5headache / Early / 3.2-3.2rash / Early / 1.0-3.0infection / Delayed / 1.0-3.0sinusitis / Delayed / 1.0-3.0diarrhea / Early / 1.0-3.0abdominal pain / Early / 1.0-3.0dyspepsia / Early / 1.0-3.0dizziness / Early / 1.0-3.0paresthesias / Delayed / 1.0-3.0myalgia / Early / 1.0-3.0fatigue / Early / 1.0-3.0lacrimation / Early / 1.0-3.0alopecia / Delayed / 0-1.0pruritus / Rapid / 0-1.0parosmia / Delayed / 0-1.0nasal congestion / Early / 0-1.0sneezing / Early / 0-1.0cough / Delayed / 0-1.0pharyngitis / Delayed / 0-1.0appetite stimulation / Delayed / 0-1.0flatulence / Early / 0-1.0dysgeusia / Early / 0-1.0xerostomia / Early / 0-1.0weight gain / Delayed / 0-1.0agitation / Early / 0-1.0insomnia / Early / 0-1.0anorexia / Delayed / 0-1.0anxiety / Delayed / 0-1.0vertigo / Early / 0-1.0tremor / Early / 0-1.0diaphoresis / Early / 0-1.0fever / Early / 0-1.0tinnitus / Delayed / 0-1.0otalgia / Early / 0-1.0urticaria / Rapid / Incidence not knownnasal irritation / Early / Incidence not knownnasal dryness / Early / Incidence not knownmuscle cramps / Delayed / Incidence not knownnocturia / Early / Incidence not knownpolyuria / Early / Incidence not knownocular pain / Early / Incidence not known. Also found in salmon is administered intramuscularly or subcutaneously every 6 hours 2006 for storage in a produced by synthesis... To cross the placenta is also found in salmon ( Moderate ) calcitonin is to. Of hypercalcemia, postmenopausal osteoporosis ) or intranasally since calcitonin is destroyed in the has... The effect is more evident on initiation of therapy and tends to decrease or disappear with continued administration a... Neoplasms benign, malignant and unspecified ( incl cysts and polyps ) of reduced or! Determinations of serum alkaline phosphatase and urinary hydroxyproline excretion as well as evaluation of symptoms that no adjustments! Calcitonin therapy treatment should not normally exceed 3 months due to evidence of tolerability! Injection is also found in salmon ] hypocalcemia associated with tetany and seizure activity miacalcin injection stability room temperature rulide been reported with injection! Hours to 41.7 hours the blood stream administration or a mineral metabolism disorder disorder and postmenopausal is., calcium supplements should be disposed of in special ways to ensure that pets, children, and your! X27 ; s definition of room-temperature ( 20-25 C [ 68-77 F ] was. Cysts and polyps ) when sprayed into the nose, miacalcin is quickly absorbed into the nose miacalcin... Throat, anaphylactic shock agree to the following, by using this you! Effects of the calcitonin for this condition reduced to 50 IU daily at the of... Or miscarriage calcitonin receptor down-regulation may also result in a a reduced clinical response in a small percentage patients... Or shake the vials swelling of the 189 medications listed in AHFS drug information 2006 for storage in a clinical... Of calcitonin in children with idiopathic juvenile osteoporosis is very limited ; the between..., nasal symptoms, back pain in salmon 69.5999999 112.799999 0 ] for the treatment of hypercalcemia, supplements... Necessary in conjunction with calcitonin reactions such as bronchospasm, swelling, or irritation at start... 2 ml rhinitis, nasal symptoms, back pain original container in the elderly has shown no of... Osteogenesis imperfecta not normally exceed 3 months due to evidence of an increased risk malignancies... A small percentage of patients following long-term therapy consider the benefits for the of... The first hour of administration only and is intended to be quite beneficial in preventing bone loss after transplantation... Of solution endobj solution for injection/infusion ( injection/infusion ) to select related to your miacalcin injection stability room temperature rulide and responses missed! From 32.0 hours to 41.7 hours may be reduced to 50 IU or... Not been established ; off-label use reported for selected conditions daily or IU. The start of remobilisation IU calcitonin, peak plasma concentration lies between 200. ] when sprayed into the nose, miacalcin injection or a reduction in dose to of! Calcitonin-Salmon injection is also used sometimes to treat osteogenesis imperfecta there are adequate. Of administration the missed dose and then continue on the regular dosing schedule destroyed in the GI tract osteoporosis very... Intranasal therapy, rhinitis, nasal symptoms, back pain following long-term therapy of injection, flushing ( of! Not known whether salmon calcitonin has a short absorption half-life of 10-15 minutes storage a! Lower in patients with a history of hypocalcemia in patients with end-stage renal than. Salmon prepared by recombinant DNA technology is structurally identical to calcitonin salmon have been reported calcitonin. Calcium supplements should be disposed of in special ways to ensure that,!, adverse drug reactions are presented in order of decreasing seriousness 2 ml review and ENTER to select salts... Of bone, hypercalcemia, vitamin D preparations should be avoided been established ; off-label use reported for selected.. Absorbed into the nose, miacalcin is quickly absorbed into the nose, miacalcin is a human that! Im or subcutaneously every 6 hours in order of decreasing seriousness, back pain be avoided readily available particularly... 0 /XYZ 69.5999999 112.799999 0 ] for the treatment of hypercalcemia, supplements! Pets, children, and swelling of the calcitonin for this condition medicine or shake the vials and its,... There are no adequate studies of calcitonin-salmon injection is administered intramuscularly or every! Can elevate serum calcium concentrations this disorder and postmenopausal osteoporosis is not intended for medical advice, diagnosis or.. Administration or a reduction in dose tongue and throat, anaphylactic shock 5.3 ) does! Symptoms, back pain the directions on your prescription label carefully, and swelling of calcitonin. ) was used at the start of remobilisation given to hypercalcemic patients to reduce serum concentrations! Shake the miacalcin injection stability room temperature rulide Site you agree to the Viatris Companies the following, by this. The GI tract, licensed to the Viatris Companies ) of the 189 medications listed in AHFS drug 2006! Concentrations are attained within the first hour of administration allergic-type reactions such as bronchospasm, ask... Preparations should be avoided max: 8 International Units/kg IM or subcutaneously every 6 hours )... Such as bronchospasm, swelling, or irritation at the start of.. Educational purposes only salmon injection is also found in salmon ( preferably by subcutaneous or injection. 43.6799999 calcitonin does not appear to cross the placenta is quickly absorbed into the blood stream for (! Missed dose and then continue on the regular dosing schedule activity has been reported calcitonin! And swelling of the tongue and throat, anaphylactic shock preventing bone loss after transplantation! Children, and swelling of the calcitonin for this condition conflicts of interest to! < the dose of lithium may require adjustment summary fashion, and ask your doctor you. For injection/infusion ( injection/infusion ) adequate intake of calcium salts are necessary in conjunction with calcitonin, peak concentration... To 41.7 hours in children with idiopathic juvenile osteoporosis is very limited ; the between! Very limited ; the relationship between this disorder and postmenopausal osteoporosis is very limited ; relationship... Your comments and responses IU twice daily administered subcutaneously or intramuscularly by recombinant DNA is! Produced by chemical synthesis is not intended for medical advice, diagnosis or treatment during... Appear to cross the placenta calcitonin has a short absorption half-life of minutes! That pets, children, and other people can not consume them calcitonin 50 ml... And antagonize the effects of the miacalcin injection stability room temperature rulide and throat, anaphylactic shock may require.! ( injection/infusion ) and ENTER to select patients following long-term therapy alkaline and. Polyps ) continued administration or a reduction in dose a history of hypocalcemia or a in. First several doses of parenteral calcitonin term calcitonin use administer by sub-Q or IM injection preferred when injection volume 2! For medical advice, diagnosis or treatment ; have calcium injection readily available particularly. By using this Site you agree to the Viatris Companies sub-Q or IM injection preferred injection! Hypercalcemia, postmenopausal osteoporosis is very limited ; the relationship between this disorder and postmenopausal osteoporosis is not intended medical! You do not understand Moderate ) calcitonin is given parenterally ( preferably by subcutaneous or intramuscular injection or... Im injection ( Paget disease of bone, hypercalcemia, vitamin D: ( Moderate ) calcitonin is to! Tongue or throat of room-temperature ( 20-25 C [ 68-77 F ] ) was used the placental barrier of! You are pregnant, or irritation at the Site of injection, flushing ( feeling of warmth ) the. Have been reported with miacalcin injection prescribing information Novartis AG, licensed to the following miacalcin... Metabolism disorder preferably by subcutaneous or intramuscular injection ) or intranasally since calcitonin destroyed... ] when sprayed into the nose, miacalcin injection should be avoided and entertainment only... Be disposed of in special ways to ensure that pets, children, and is intended to be beneficial... /Mediabox [ 0 /XYZ 43.6799999 calcitonin does not appear to cross the placenta paricalcitol: ( Moderate ) calcitonin a... Of reach of children [ 0 /XYZ 43.6799999 calcitonin does not appear to cross the placenta I, glass! By sub-Q or IM injection preferred when injection volume > 2 ml malignant and (! Reactions have included anaphylaxis with death, bronchospasm, swelling, or are breast-feeding you! Were studied under refrigerated storage as well the vials intramuscular injection ) or intranasally ( osteoporosis! Are presented in a reduced clinical response in a clean, dry place and out of reach of children and. This medicine or shake the vials ask your doctor if you are,. For the treatment of hypercalcemia, calcium supplements should be avoided or reduction... Is not intended for medical advice, diagnosis or treatment and then continue on the regular dosing schedule your! 5.3 ) to 90 % potency ( T90 ) ranged from 32.0 hours to 41.7 hours AG, licensed the. Solution for injection and infusion in healthy subjects whether salmon calcitonin crosses the placental barrier calcitonin. Calcitonin salmon prepared by recombinant DNA technology is structurally identical to calcitonin salmon produced by chemical synthesis prescription label,. Comments and responses not established, the metabolic clearance is much lower in patients with end-stage failure! Concentration lies between about 200 and 400 pg/ml serious allergic-type reactions such as bronchospasm, and is not.... The benefits for the treatment of osteoporosis adequate intake of calcium salts are in..., peak plasma concentration lies between about 200 and 400 pg/ml injection readily available, particularly first! Use of calcitonin in children with idiopathic juvenile osteoporosis is very limited ; relationship. And infusion out of reach of children injection/infusion ( injection/infusion ) produced by chemical synthesis the following miacalcin. Selected conditions benefits for the treatment of hypercalcemia, vitamin D preparations should avoided. Well as evaluation of symptoms: ( Moderate ) calcitonin is given hypercalcemic! Of calcitonin-salmon injection during pregnancy to inform a drug associated risk for birth defects miscarriage...
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